The Goldfields Highway between Meekatharra and Wiluna has been closed due to flooding.
Main Roads says the closure will be reassessed later today.
Motorists are urged to avoid the area where possible.
© ABC 2013
09:57 EDT Cyclone Marcia may have disrupted daily life for Tom and Rita Edmistone, whose house is still in tatters, but it has failed to rock their 60-year marriage.